Micronization potentiates curcumin’s anti-seizure effect and brings an important advance in epilepsy treatment

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Micronization potentiates curcumin’s anti-seizure effect and brings an important advance in epilepsy treatment

Epilepsy is one of the most common neurological diseases, and current antiepileptic drugs fail to suppress seizure occurrence in around one third of epileptic patients. Curcumin is a phytochemical with promising effects on epilepsy treatment. However, its application has been hindered by its low bioavailability. In order to improve curcumin's anti-seizure properties, increasing its bioavailabil...

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Epilepsy is a neurological disease of the central nervous system. It is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. In the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

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Received: November 6, 2015; Accepted: August 26, 2016; Published online: October 28, 2016

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Received: December 26, 2016; Accepted: June 1, 2017

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Epilepsy & Seizure

The relationship between epilepsy and psychoses has long been debated, and descriptions regarding symptoms of interictal psychoses in patients with epilepsy date back to even the Babylonian era. However, scant attention has been paid to this issue lately. Adequate recognition of psychoses in epilepsy is essential for physicians caring for the affected patients, because the impact on their quali...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2018

ISSN: 2045-2322

DOI: 10.1038/s41598-018-20897-x